M102 has four sets of translational data from three in vivo pharmacology studies in ALS models and one in vitro study in the ALS patient cellular model. All datasets indicate strong efficacy in both familial and sporadic ALS. Particularly in the TDP-43 mouse model, M102 has stopped disease progression and reverted disease animals back towards the healthy state. TDP-43 proteins exist in 97% of all ALS patients.

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