M102 is a dual activator of the Nrf2 and HSF1 pathways, and an inhibitor of NFkB pathway, which are newly understood disease-modifying pathways that are downregulated in ALS and affect these nine ALS pathomechanisms. 

By Nrf2 and HSF1 activation, M102 reduces oxidative stress and inflammation, enhances mitochondrial biogenesis and initiates autophagy. In addition, M102 refolds misfolded proteins, disaggregates aggregated proteins, and clears misfolded and aggregated proteins. 

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